Scrotum Botox is also known as Scrotox these days. It is a treatment done to enhance the size and aesthetic appearance of the scrotum. Botulinum toxin (Botox) is injected into the scrotum to tighten the skin and make it aesthetically more appealing. Scrotum Botox is a quick treatment involving only an injection to the target area and can be done on an outpatient basis.